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The problem with line art is that you don't have the luxury of anti-aliasing (eliminating jagged edges with the process of adding steps of gray). Scan line art at the same resolution and size as the output device. If you are printing the work at 100% and at 600 dpi, scan at 100% at 600dpi. If the final work is to be 50% of the original size, adjust accordingly, i.e.: scan 50% at 600 dpi for an image to be 1/2 the size of the original with 600 dpi output; or scan at 100% at 300 dpi and reduce the image by 50% in your image manipulation program